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Innate Immunity Pathways
The Angiopoietins are a new family of Growth Factor ligands that bind to TIE2/Tek TRK (Receptor Tyrosine Kinase).
CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily.
FAS (also called Apo1 or CD95) is a death domain containing member of the Tumor Necrosis Factor Receptor superfamily.
Adhesion and Diapedesis of granulocytes have mostly been analyzed in context to non-lymphoid endothelium.
GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.
IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.
IL-22 is a member of the IL-10 family of cytokines and exerts multiple effects on the immune system.
Pathogenesis is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet.
Transport of plasma proteins and solutes across the endothelium involves two different routes: transcellular and paracellular junctions.
TWEAK is a cell surface-associated protein belonging to the TNF superfamily and has multiple biological activities.