Browse Pathways by Area of Biology
Cytokines, Chemokines & Growth Factors Pathways
BMPs (Bone Morphogenetic Proteins) are a large subclass of the TGF-Beta (Transforming Growth Factor-Beta) super family.
Cytokines have been classified on the basis of their biological responses into pro- or anti-inflammatory cytokines, depending on their effects on immunocytes.
One of the best-characterized modulators of angiogenesis is the heparin-binding FGF (Fibroblast Growth Factor).
IL-2 is a cytokine that stimulates the growth, proliferation and differentiation of T cells, B cells, NK cells, and other immune cells.
IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.
IL-10 is a pleiotropic cytokine with important immunoregulatory functions and whose activities influence many immune cell types.
IL-22 is a member of the IL-10 family of cytokines and exerts multiple effects on the immune system.
Interferons are pleiotropic cytokines best known for their ability to induce cellular resistance to viral infection.
RANKL and its receptor RANK are key regulators of bone remodeling, and are essential for the development and activation of osteoclasts.
RANKL induces the differentiation of osteoclast precursor cells and stimulates the resorption function and survival of mature osteoclasts.
Members of the TGF beta family play an important role in the development, homeostasis and repair of most tissues.
TNF is a multifunctional proinflammatory cytokine with effectson lipid metabolism, coagulation, insulin resistance and endothelial function.
The TNF Superfamily consists of 19 members that signal through 29 receptors that are members of the TNFR Superfamily.
TWEAK is a cell surface-associated protein belonging to the TNF superfamily and has multiple biological activities.