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Pathways


CCG

Cytokines, Chemokines & Growth Factors Pathways

BMP Pathway

BMP Pathway

BMPs (Bone Morphogenetic Proteins) are a large subclass of the TGF-Beta (Transforming Growth Factor-Beta) super family.

Cytokine Network

Cytokine Network

Cytokines have been classified on the basis of their biological responses into pro- or anti-inflammatory cytokines, depending on their effects on immunocytes.

FGF Pathway

FGF Pathway

One of the best-characterized modulators of angiogenesis is the heparin-binding FGF (Fibroblast Growth Factor).

IL-2 Gene Expression in Activated and Quiescent T Cells

IL-2 Gene Expression in Activated and Quiescent T Cells

IL-2 is a cytokine that stimulates the growth, proliferation and differentiation of T cells, B cells, NK cells, and other immune cells.

IL-6 Pathway

IL-6 Pathway

IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.

IL-10 Pathway

IL-10 Pathway

IL-10 is a pleiotropic cytokine with important immunoregulatory functions and whose activities influence many immune cell types.

IL-22 Pathway

IL-22 Pathway

IL-22 is a member of the IL-10 family of cytokines and exerts multiple effects on the immune system.

Interferon Pathway

Interferon Pathway

Interferons are pleiotropic cytokines best known for their ability to induce cellular resistance to viral infection.

RANK Pathway

RANK Pathway

RANKL and its receptor RANK are key regulators of bone remodeling, and are essential for the development and activation of osteoclasts.

RANK Signaling in Osteoclasts

RANK Signaling in Osteoclasts

RANKL induces the differentiation of osteoclast precursor cells and stimulates the resorption function and survival of mature osteoclasts.

TGF Beta Pathway

TGF Beta Pathway

Members of the TGF beta family play an important role in the development, homeostasis and repair of most tissues.

TNF Signaling Pathway

TNF Signaling Pathway

TNF is a multifunctional proinflammatory cytokine with effectson lipid metabolism, coagulation, insulin resistance and endothelial function.

TNF Superfamily Pathway

TNF Superfamily Pathway

The TNF Superfamily consists of 19 members that signal through 29 receptors that are members of the TNFR Superfamily.

TWEAK Pathway

TWEAK Pathway

TWEAK is a cell surface-associated protein belonging to the TNF superfamily and has multiple biological activities.

VEGF Family Ligands and Receptor Interactions

VEGF Family of Ligands and Receptor Interactions

VEGF (Vascular Endothelial Growth Factor) is a highly conserved genetic pathway that has evolved from simple to complex systems.