Although cancer cells are derived from normal tissues, the molecular changes carried out in cancer cells should allow the immune system to recognize them as foreign and to extinguish them. In fact, many nascent cancers are eliminated by the immune system before they mature. Yet, unfortunately, cancers do develop.
The immune system either fails to recognize the tumor antigens expressed by each patient's unique and frequently changing population of cancer cells or cancer cells are actively evading the immune response.
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|The Cancer Cycle
Interactions between cancer and tumor cells
The immune system's double-edged nature towards tumor development
The complex cellular ecosystem within a tumor
Checkpoint control and the interface between tumors and cells of the immune system