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Tfh Cells

T follicular helper (Tfh) cells are a regulatory class of specialized effector T helper cells that are essential in the development of antigen-specific effector and memory B cell responses. Tfh cells are found enriched within the edges of the B cell zones of secondary lymphoid organs such as the lymph nodes, spleen, and Peyer’s patches. These cells regulate humoral immunity, particularly germinal center reactions, and play a role in the development of long-term antibody responses. Upon antigen-specific stimulation, Tfh cells migrate to the follicular regions of secondary lymphoid tissues, where they form stable contacts with antigen-primed B cells and release IL-4, IL-10, IFN gamma, and IL-21 to stimulate mature B cells into forming germinal centers and undergoing antibody class-switching.

Tfh cells are defined phenotypically by high expression of CXCR5 (CD185, CXCL13 receptor), Bcl-6, and IL-21 along with low CCR7 (CD197) expression. Activated CXCR5hiCCR7lo T cells migrate to the B cell follicles in response to high levels of CXCL13, which is secreted by follicular stromal cells. Nevertheless, Tfh cells require IL-6, IL-21, and B cell interaction for complete development. A key transcription factor involved in this differentiation is Bcl-6, which regulates the changes in CXCR5 and CCR7 expression required for T cell migration to the follicle. Moreover, Bcl-6 promotes Tfh cell development by repressing Blimp-1, ROR gamma t, T-bet, and GATA3, as well as several miRNAs. Interestingly, Bcl-6 also plays a critical role in germinal center B cell differentiation. Because they mediate antigen-specific B cell immunity, Tfh cells have been linked to diseases such as angioimmunoblastic T cell lymphoma, as well as autoimmune disorders including systemic lupus erythematosus and Sjogren's syndrome.



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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse High Sensitivity Panel (5 plex)

Multiplex EPXS050-22199 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

anti-mouse IL-6

6B4 IGH 54 ELISA, FA BMS178* RUO

anti-human IL-6/FITC

B-E8 FC, FA BMS130FI* RUO

Human IL-6 High Sensitivity ELISA

ELISA BMS213HS* RUO

Mouse IL-6 High Sensitivity ELISA

ELISA BMS603HS* RUO

Human IL-6 Instant ELISA

ELISA BMS213INST* RUO

Monkey IL-6 Instant ELISA

ELISA BMS641INST* RUO

Human IL-6 Instant ELISA

ELISA BMS213INSTCE* CE

Human IL-6 Matched Antibody Pairs

ELISA BMS213/2MST* RUO

Monkey IL-6 Platinum ELISA

ELISA BMS641/2* RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents