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Hematopoietic Stem Cells

It is now known that Hematopoietic Stem Cells (HSCs) progress through defined stages of maturation that result in gradual loss of multi-lineage potential, and commitment to various blood cell phenotypes. Mouse HSCs were first isolated as part of the bone marrow fraction depleted of lineage positive cells. Subsequently, it was discovered that the lineage-negative fraction could be significantly enriched for HSCs by further selecting the lin-Sca-1+c-Kit+ (LSK) population of bone marrow. In 2005, it was demonstrated by Morrison et al that a combination of the SLAM family of proteins could also be used to efficiently identify and isolate HSCs. They found the CD150+CD48-CD244-CD41- fraction of mouse bone marrow to be significantly enriched for long-term reconstituting ability. In humans, the isolation of a lin-CD34+CD90+ progenitor cell resulted in the purification of a homogeneous HSC population. The critical test for HSCs is in their ability to clinically rescue myelo-ablated hosts from hematopoietic failure, and establish long-term multi-hematopoietic lineage reconstitution.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse BP-1 Biotin

6C3 FC 13-5891 RUO

Anti-Mouse BP-1 FITC

6C3 FC 11-5891 RUO

Anti-Mouse BP-1 PE

6C3 FC 12-5891 RUO

Anti-Mouse BP-1 PerCP-eFluor® 710

6C3 FC 46-5891 RUO

Anti-Mouse BP-1 Purified

6C3 FC, IHC, IP 14-5891 RUO

Anti-Canine CD34 PE

1H6 FC 12-0340 RUO

CD34 APC

4H11 (APG) FC 9017-0349 CE

Anti-Human CD34 APC

4H11 FC 17-0349 RUO

CD34 APC

4H11 (APG) 8017-0349 ASR

Anti-Human CD34 APC-eFluor® 780

4H11 FC 47-0349 RUO

Anti-Human CD34 Biotin

4H11 FC 13-0349 RUO

Anti-Human CD34 FITC

4H11 FC 11-0349 RUO

CD34 FITC

4H11 (APG) FC 8011-0349 ASR

CD34 FITC

4H11 (APG) FC 9011-0349 CE

Anti-Human CD34 PE

4H11 FC 12-0349 RUO

CD34 PE

4H11 (APG) FC 9012-0349 CE

CD34 PE

4H11 (APG) 8012-0349 ASR

Anti-Human CD34 PE-Cyanine7

4H11 FC 25-0349 RUO

CD34 PE-Cyanine7

4H11 (APG) FC 8025-0349 ASR

Anti-Human CD34 PE-eFluor® 610

4H11 FC 61-0349 RUO

CD34 PerCP

4H11 FC 9043-0349 CE

Anti-Human CD34 PerCP-eFluor® 710

4H11 FC 46-0349 RUO

CD34 PerCP-eFluor® 710

4H11 (APG) FC 9046-0349 CE

Anti-Human CD34 Purified

4H11 FC, FA, WB 14-0349 RUO

Anti-Human CD34 eFluor® 450

4H11 FC 48-0349 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents