Anti-Smooth Muscle Myosin Alexa Fluor® 647

Also known as: smooth muscle myosin heavy chains, SM1 and SM2 isoforms

Clone: SMMS-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-6400

Cat. No.	Size
51-6400-80	25 ug
51-6400-82	100 ug
Please inquire about custom configurations or bulk packaging.

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Immunohistochemistry on formalin-fixed paraffin embedded human infiltrating ductal carcinoma, using...View More

Description

Description: This SMMS-1 monoclonal antibody reacts with both isoforms of the human smooth muscle myosin heavy chain (SM1 and SM2) structural proteins, which are components of the contractile apparatus in smooth muscle cells. Smooth muscle myosin heavy chains are expressed by myoepithelial cells and also serve as the terminal differentiation marker for smooth muscle cells. In normal breast tissue, myoepithelial cells compose the outer layer of the lumen lining. In benign and in situ breast lesions, the intact myoepithelial layer stains with SMMS-1 and the loss of this staining indicates invasive cancer. This SMMS-1 antibody has also been reported to cross-react with bovine, canine, feline, and rat smooth muscle myosin heavy chains.

Details

Host	Mouse
Isotype	IgG1
Reactivity	Bovine, Canine, Rat
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 - 647 nm
Concentration	0.2 mg/mL
Formulation	aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Immunohistochemical Staining, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-6400	Anti-Smooth Muscle Myosin Purified			IHC, WB	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
51-4714	Mouse IgG1 K Isotype Control Alexa Fluor® 647 (Discontined. Refer to Cat. No. 50-4714)	633 - 647 nm	668 nm	FC, ICC, IHC	RUO
00-4955	IHC Antigen Retrieval Solution – Low pH (10X)			IHC	GPR

References

References: Kalof AN, Tam D, Beatty B, Cooper K. Immunostaining patterns of myoepithelial cells in breast lesions: a comparison of CD10 and smooth muscle myosin heavy chain. J Clin Pathol. 2004 Jun;57(6):625-9. (SMMS-1, IHC-P)

Lazard D, Sastre X, Frid MG, Glukhova MA, Thiery JP, Koteliansky VE. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):999-1003. (SMMS-1, IHC-F)

View More Products

Antigens	Area of Biology	Formats
Myosin	Cell Structure	Alexa Fluor 647