Anti-Rat MHC Class II PerCP-eFluor® 710

Description: This OX17 monoclonal antibody reacts with the I-E molecule of rat MHC Class II, which is also known as RT1-D. MHC Class II is expressed on antigen presenting cells such as B cells, dendritic cells, and macrophages.

The OX17 antibody has been reported to possess blocking activity. Moreover, crossblocking studies suggest that OX17 and HIS19 recognize different epitopes.

References: Massé D, Voisine C, Henry F, Cordel S, Barbieux I, Josien R, Meflah K, Grégoire M, Lieubeau B. Increased vaccination efficiency with apoptotic cells by silica-induced, dendritic-like cells. Cancer Res. 2002 Feb 15;62(4):1050-6. (OX17, FC, ICC)

Offner H, Brostoff SW, Vandenbark AA. Antibodies against I-A and I-E determinants inhibit the activation and function of encephalitogenic T-lymphocyte lines. Cell Immunol. 1986 Jul;100(2):364-73. (OX17, FA)

Fukumoto T, McMaster WR, Williams AF. Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus. Eur J Immunol. 1982 Mar;12(3):237-43. (OX17)