Description: This FlowCytomix Simplex Kit is designed for the measurement of IP-10 in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Rat Basic Kit (cat. BMS8441FF), this kit can be used to detect IP-10 alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.
In this kit, the antibodies are mouse-specific and the standards are recombinant mouse proteins. The antibodies are cross-reactive with rat cytokines.
This kit contains bead population A3.
IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. The Interferon-gamma inducible protein -10kD (IP-10) displays pleiotropic functions including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis.
Through this inhibitory effect on neovascularization IP-10 exhibits anti-tumoral effects. It shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer’s disease.
Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.