Rat IL-2 Platinum ELISA

Description: The rat IL-2 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of rat IL-2. The rat IL-2 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Interleukin-2 (IL-2) plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 plays a pivotal role in for the expansion of most T-cells, natural killer cells and B-cells during certain phases of their response. Antigen-specific proliferation of helper and cytotoxic T-lymphocytes following stimulation is critically dependent on IL-2 expression, secretion, and binding to receptors in an autocrine fashion on the surface of T cells. Apart from its most important role to mediate antigen specific T lymphocyte proliferation, IL-2 modulates the expression of interferon gamma and major histocompatibility antigens, stimulates proliferation and differentiation of activated B and NK cells, augments natural killer cell activity and inhibits granulocyte-macrophage colony formation. Alterations in the ability of T cells to synthesize IL-2 have been observed in physiologic and pathologic states.

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Tigges,M.A.; Casey,L.S.; Koshland,M.E.. Mechanism of interleukin-2 signaling: mediation of different outcomes by a single receptor and transduction pathway. Science 1989;243:781-786. (Link)

Gressler,V.H.; Weinkauff,R.E.; Franklin,W.A.; Golomb,H.M.. Modulation of the expression of major histocompatibility antigens on splenic hairy cells--differential effect upon in vitro treatment with alpha-2b-interferon, gamma-interferon, and interleukin-2. Blood 1988;72:1048-1053. (Link)

Phadke,K.; Carlson,D.G.; Gitter,B.D.; Butler,L.D.. Role of interleukin 1 and interleukin 2 in rat and mouse arthritis models. J.Immunol. 1986;136:4085-4091. (Link)

Cornaby,A.; Simpson,M.; Vann,Rice R.; Dempsey,R.; Madras,P.; Jenkins,R.; Monaco,A.. Interleukin 2 levels and urine cytology distinguish between cyclosporine toxicity and rejection in renal and liver allograft recipients. Transplant Proc. 1988;20:827-830. (Link)