Rat IL-17A Recombinant Protein Carrier-Free

Description: Interleukin-17A (IL-17A, also known as CTLA-8 and IL-17) is a member of the IL-17 family of proinflammatory cytokines. It is most similar to IL-17F, another member of the family with which it shares 50% sequence homology. Both cytokines exist as homodimers and individual subunits from each protein can also associate into a heterodimer known as IL-17AF.

Expression of IL-17A is most often associated with the Th17 subset of CD4⁺ T cells, but has also been observed in CD8⁺ T cells, γδ T cells, and neutrophils. IL-17A is important as a neutrophil activator, and it induces inflammatory cytokine production in epithelial cells, endothelial cells, and fibroblasts through NF-κB signaling. IL-17A and Th17 cells have been implicated in various autoimmune disorders.

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Gaffen SL. An overview of IL-17 function and signaling. Cytokine. 2008 Sep; 43(3): 402-7.

Roark CL, Simonian PL, Fontenot AP, Born WK, O’Brien RL. gammadelta T cells: an important source of IL-17. Curr Opin Immuno. 2008 Jun; 20(3): 353-7