Description: This FlowCytomix Simplex Kit is designed for the measurement of Rat IL-17A in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Mouse Basic Kit (cat. BMS8440FF), this kit can be used to detect IL-17A alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.
This kit contains bead population A10.
IL-17A, a homodimeric cytokine of about 32 kDa, is largely produced by activated memory T lymphocytes, but stimulates innate immunity and host defense. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction, as well as increased survival locally. IL-17A and IL-17F production by T lymphocytes is regulated by IL-23 independent of T cell receptor activation. The Th1 and Th2 cell classification has until recently provided the framework for understanding CD4+ T cell biology and the interplay between innate and adaptive immunity. The Th17 lineage produces interleukin 17, which is highly proinflammatory and induces severe autoimmunity. Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis.
