Anti-Rat IgM Purified

Description: The HIS40 monoclonal antibody reacts with the μ heavy chain of rat IgM. It does not react with other classes of rat immunoglobulin including IgD, IgG or IgA. IgM is expressed intracellularly, during early stages of B lymphopoiesis, and then on the surface of more mature B cells in the bone marrow and peripheral B cells. Fluorochrome conjugated HIS40 is used as a detection secondary for rat IgM primary antibodies.

References: Kroese, FGM. 2001. Personal communication. Kroese FG, Butcher EC, et al. 1990. The rat B cell system: the anatomical localization of flow cytometry-defined B cell subpopulations. Eur J Immunol. 20(7): 1527-34. Kroese, FG, Wubbena AS, et al. 1987. B lymphocyte differentiation in the rat: production and characterization of monoclonal antibodies to B lineage-associated antigens. Eur J Immunol. 17(7): 921-8.