Rat CXCL1 FlowCytomix Simplex

Description: This FlowCytomix Simplex Kit is designed for the measurement of Rat CXCL1 in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Rat Basic Kit (cat. BMS8441FF), this kit can be used to detect CXCL1 alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.

In this kit, the antibodies are mouse-specific and the standards are recombinant mouse proteins. The antibodies are cross-reactive with rat cytokines.

This kit contains bead population A5.

The Keratinocyte chemoattractant gene is a member of the small inducible gene family of regulated chemokines. It encodes a growth factor and chemoattractant that appears to mediate inflammatory and immune responses in vitro and in vivo.
Chemokine KC (CXCL1) has been considered to be a murine homologue of human GRO/MGSA and was identified as chemoattractant for monocytes and neutrophils.

Increased KC expression has been found to be associated with neutrophil influx in various inflammatory conditions. An important role for KC/CXCL1 has been shown in experimental model of multiple sclerosis as a chemoattractant of destructive immune cells. Data further indicate that KC/GRO chemokines are the principal chemokines induced by LPS and pro-inflammatory cytokines IL-1 and TNF via NFkappaB signalling in ovarian surface epithelial cancer cells.