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Anti-Rat CD8a Purified

Also known as: CD8 alpha

Clone: OX8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-0084

Cat. No. Size
14-0084-82 100 ug
14-0084-80 25 ug
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Data for Anti-Rat CD8a Purified.

Description

Description: The OX8 monoclonal antibody reacts with rat CD8 alpha. CD8 alpha is a member of the immunoglobulin superfamily which heterodimerizes with CD8 beta to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages. CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck.

Details
Host Mouse
Isotype IgG1, kappa
Reactivity Rat
Conjugate Purified
Reported Applications Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Functional Assays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
11-0084 Anti-Rat CD8a FITC 488 nm FC RUO
25-0084 Anti-Rat CD8a PE-Cy7 488 - 561 nm 775 nm FC RUO
46-0084 Anti-Rat CD8a PerCP-eFluor® 710 488 nm 710 nm FC RUO
12-0084 Anti-Rat CD8a PE 488 - 561 nm FC RUO
17-0084 Anti-Rat CD8a APC 633 - 647 nm 660 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
11-4011 Anti-Mouse IgG FITC 488 nm FC RUO
14-4714 Mouse IgG1 K Isotype Control Purified FC, ICC, IHC, IP, WB RUO
References

References: Johnson P, Gagnon J, Barclay AN, Williams AF. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J. 1985 Oct;4(10):2539-45. (OX8, protein purification, PubMed)

May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, Taurog JD. CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol. 2003 Jan 15;170(2):1099-105. (OX8, FC, FA, PubMed)

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