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Anti-Rat CD8a PE-Cy7

Also known as: CD8 alpha

Clone: OX8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-0084

Cat. No. Size
25-0084-80 25 ug
25-0084-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Rat CD8a PE-Cy7.

Staining of rat splenocytes with Anti-Rat CD4 FITC (cat. 11-0040) and 0.125 ug of Mouse IgG1 kappa...View More

  • Data for Anti-Rat CD8a PE-Cy7.
Description

Description: The OX8 monoclonal antibody reacts with rat CD8α. CD8α is a member of the immunoglobulin superfamily which heterodimerizes with CD8β to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages. CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck.

Details
Host Mouse
Isotype IgG1
Reactivity Rat
Conjugate PE-Cy7
Laser Blue Laser, Green Laser, Yellow-Green Laser
Emit 760 nm
Excite 488 - 561 nm
Legal FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
17-0084 Anti-Rat CD8a APC 633 - 647 nm 660 nm FC RUO
12-0084 Anti-Rat CD8a PE 488 - 561 nm 575 nm FC RUO
14-0084 Anti-Rat CD8a Purified FC, IHC, FA RUO
16-0084 Anti-Rat CD8a Functional Grade Purified (To Be Discontinued; refer to Cat. No. 14-0084) FC, FA RUO
References

References: Johnson P, Gagnon J, Barclay AN, Williams AF. Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J. 1985 Oct;4(10):2539-45. (OX8, protein purification, PubMed)

May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, Taurog JD. CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol. 2003 Jan 15;170(2):1099-105. (OX8, FC, FA, PubMed)

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