Anti-Rat CD5 APC

Description: The HIS47 monoclonal antibody reacts with rat CD5, a 67 kDa surface protein expressed by a majority of thymocytes and mature T cells. While mouse and human CD5 is also expressed on a small subset of B cells called B-1 cells, such CD5⁺ B cell subset has not been identified in the rat so far. CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction.

References:
Vermeer LA, de Boer NK, Bucci C, Bos NA, Kroese FG, Alberti S. 1994. MRC OX19 recognizes the rat CD5 surface glycoprotein, but does not provide evidence for a population of CD5bright B cells. Eur J Immunol. 24(3):585-92.

Vermeer L, Bos N, Kroese F, Bucci C, Alberti S. 1992. Molecular cloning of the rat CD5 gene. Ann N Y Acad Sci. 651:82-3.
de Boer NK, Ammerlaan WA, Meedendorp B, Kroese FG. 1992. CD5 B cells in the rat? Ann N Y Acad Sci. 651:157-9.