Anti-Rat CD45R (B220) FITC

Description: The HIS24 monoclonal antibody reacts with an isoform of CD45 expressed by rat B cells. The antigen recognized by HIS24 is found on B cells from the early stage of B cell development in the bone marrow to mature peripheral B cells, but not on plasma cells. HIS24 recognizes a 205 kDa protein by immunoblotting. CD45, also known as Leukocyte Common Antigen (LCA), has tyrosine phosphatase enzymatic activity in its cytoplasmic portion and plays an important role in activation of lymphocytes.

References: Kroese FG, Butcher EC, Lalor PA, Stall AM, Herzenberg LA. The rat B cell system: the anatomical localization of flow cytometry-defined B cell subpopulations. Eur J Immunol. 1990 Jul;20(7):1527-34.

Kroese FG, Wubbena AS, Opstelten D, Deenen GJ, Schwander EH, De Leij L, Vos H, Poppema S, Volberda J, Nieuwenhuis P. B lymphocyte differentiation in the rat: production and characterization of monoclonal antibodies to B lineage-associated antigens.Eur J Immunol. 1987 Jul;17(7):921-8.

Kroese FG, Opstelten D, Wubbena AS, Deenen GJ, Aten J, Schwander EH, de Leij L, Nieuwenhuis P. Monoclonal antibodies to rat B lymphocyte (sub-) populations. Adv Exp Med Biol. 1985;186:81-9.