Anti-Rat CD45.2 PE (To be Discontinued)

Description: The HIS41 monoclonal antibody reacts with all isoforms of the rat CD45 molecule, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding mature erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in signaling and activation of lymphocytes. HIS41 reacts with strains expressing the RT7.2 alloantigen (BUF, LOU, and WF), but not strains expressing the RT7.1 alloantigen (ACI, AO, BN, DA, DZB, LEW, MAXX, PVG, SHR, and WAG).

References:
Kampinga, J., F.G.M. Kroese, G.H. Pol, D. Opstelten, H.G. Seijen, J.H.A. Boot, B. Roser, P. Nieuwenhuis, and R. Aspinall. 1990. RT7-defined alloantigens in rats are part of the leukocyte common antigen family. Scand. J. Immunol. 31:699-710.
Giezeman-Smits, K. M., A. Gorter, R. L. P. van Vlierberghe, J. D. H. v. Eendenburg, A. M. M. Eggermont, G. J. Fleuren, P. J. K. Kuppen. 1999. The Regulatory Role of CD45 on Rat NK Cells in Target Cell Lysis. J. Immunol. 163:71-76.
Butcher, G.W. 1987. A list of monoclonal antibodies specific for alloantigens of the rat. J. Immunogenet. 14:163-176.