Anti-Rat CD28 Biotin

Description: The JJ319 monoclonal antibody reacts with the rat CD28 molecule, expressed by thymocytes, mature T cells, and a subset of NK cells. CD28 is a ligand for CD80 (B7-1) and CD86 (B7-2) and is a potent costimulator of T cells. Signaling through CD28 augments IL-2 and IL-2 receptor expression as well as cytotoxicity of CD3-activated T cells. No reactivity of JJ319 is observed on mouse T cells.

References: Tacke, M., G. Hanke, T. Hanke, T. Hunig. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol. 1997. 27:239-47.

Mitnacht, R., M. Tacke, T. Hunig. Expression of cell interaction molecules by immature rat thymocytes during passage through the CD4+8+ compartment: developmental regulation and induction by T cell receptor engagement of CD2, CD5, CD28, CD11a, CD44, and CD53. Eur J Immunol. 1995. 25:328-32.

Tacke, M., G.J. Clark, M.J. Dallman, T Hunig. Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporine A sensitivity of costimulated T cell responses by phorbol ester. J Immunol. 1995.154:5121-27.