Anti-Rat CD11a PerCP-eFluor® 710

Description: This WT.1 monoclonal antibody reacts with rat CD11a, which is also known as lymphocyte function-associated antigen-1 (LFA-1) alpha chain. CD11a is expressed on all leukocytes. LFA-1, which is composed of CD11a and CD18 (also known as integrin beta 2), is an important adhesion molecule involved in lymphocyte and granulocyte function. Studies have demonstrated that LFA-1 binds CD54 (aka ICAM-1), CD102 (aka ICAM-2), and CD50 (aka ICAM-3).

References: Takahashi D, Azuma H, Sakai H, Sou K, Wakita D, Abe H, Fujihara M, Horinouchi H, Nishimura T, Kobayashi K, Ikeda H. Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture conditions. J Pharmacol Exp Ther. 2011 Apr;337(1):42-9. (WT.1, FC)

Zakrzewicz A, Wilhelm J, Blöcher S, Wilczynska J, Wilker S, Dietrich H, Weimer R, Padberg W, Grau V. Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys. Immunobiology. 2011 May;216(5):613-24. (WT.1, FC)

Sanchez-Madrid F, Simon P, Thompson S, Springer TA. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1;158(2):586-602.