Anti-p53DINP1 Purified

Description: The polyclonal antibody recognizes human, mouse and rat p53DINP1 (p53-dependent damage-inducible nuclear protein 1) also known as TP53INP1 (tumor protein p53 inducible nuclear protein 1). This protein exists as two alternatively spliced isoforms, TP53INP1alpha and TP53INP1beta, found in the nucleus regulating p53 transcriptional activity. Overexpression leads to apoptosis and cell cycle arrest in G1 while downregulation has been observed in the early stages pancreatic ductal carcinoma. Decreased p53DINP1expression results in increased cell migration and hence metastasis, thereby indicating a role for p53DINP1 in apoptosis and tumor suppression.

This antibody was generated using a peptide at the amino terminus of human p53DINP1 and can recognize the alpha isoform at about 27 kDa and in some lysates also the beta form at about 18 kDa.

References: Meritxell Gironella, Mylène Seux, Min-Jue Xie, Carla Cano, Richard Tomasini, Julien Gommeaux, Stephane Garcia, Jonathan Nowak, Man Lung Yeung, Kuan-The Jeang, Amandine Chaix, Ladan Fazli, Yoshiharu Motoo, Qing Wang, Palma Rocchi, Antonio Russo, Martin Gleave, Jean-Charles Dagorn, Juan L. Iovanna, Alice Carrier, Marie-Josèphe Pébusque, Nelson J. Dusetti Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development Proc Natl Acad Sci U S A. 2007 October 9; 104(41): 16170–16175

Seux M, Peuget S, Montero MP, Siret C, Rigot V, Clerc P, Gigoux V, Pellegrino E, Pouyet L, N'guessan P, Garcia S, Dufresne M, Iovanna JL, Carrier A, André F, Dusetti NJ.TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression. Oncogene. 2011 Jul 7;30(27):3049-61

Tomasini R, Samir AA, Pebusque MJ, Calvo EL, Totaro S, Dagorn JC, Dusetti NJ, Iovanna JL. P53-dependent expression of the stress-induced protein (SIP). Eur J Cell Biol. 2002 May;81(5):294-301.

Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol Cell. 2001 Jul;8(1):85-94.