Anti-Oligodendrocyte Marker O1 Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. 50-6506)

Clone: O1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-6506

Cat. No.	Size
51-6506-80	25 ug
51-6506-82	100 ug
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Immunocytochemistry of fixed, differentiated OLN93 cells using 20 ug/mL of Mouse IgM Isotype Control...View More

Description

Description: This O1 monoclonal antibody reacts with galactocerebroside and other lipids found on late oligodendrocyte precursors. O1 has been reported to react to all species tested (rat, mouse, human, chicken). Oligodendrocytes function as myelin-producing cells within the central nervous system ensheathing the axons of neurons with myelin in order to facilitate rapid axonal conduction. O1 and O4 monoclonal antibodies serve as stage-specific markers of oligodendrocyte development with O4 marking early oligodendrocyte progenitors and O1-labeling late oligodendrocyte progenitors. O4-positive cells differentiate to become O1-positive, which can in turn become mature oligodendrocytes.

Details

Host	Mouse
Isotype	IgM
Reactivity	Chicken, Human, Mouse, Rat
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 - 647 nm
Concentration	0.2 mg/mL
Formulation	aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections, Immunocytochemistry

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
50-6506	Anti-Oligodendrocyte Marker O1 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 - 647 nm	668 nm	FC, ICC, IHC	RUO
14-6506	Anti-Oligodendrocyte Marker O1 Purified			FC, ELISA, ICC, IHC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
50-4752	Mouse IgM Isotype Control eFluor® 660	633 nm	668 nm	FC, IHC	RUO

References

References: Yang Y, Lewis R, Miller RH. Interactions between oligodendrocyte precursors control the onset of CNS myelination. Dev Biol. 2011 Feb 1;350(1):127-38. (O1, IHC-F)

Mela A, Goldman JE. The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination. J Neurosci. 2009 Sep 9;29(36):11172-81. (O1, ICC)

Bansal R, Warrington AE, Gard AL, Ranscht B, Pfeiffer SE. Multiple and novel specificities of monoclonal antibodies O1, O4, and R-mAb used in the analysis of oligodendrocyte development. J Neurosci Res. 1989 Dec;24(4):548-57.

Sommer I, Schachner M. Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev Biol. 1981 Apr 30;83(2):311-27.

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Antigens	Formats
Oligodendrocyte Marker	Alexa Fluor 647