Anti-Mouse VEGF Receptor 3 Purified

Description: The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4. This 195 kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase (RTK) family. During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis. VEGF-C and VEGF-D bind to and activate VEGFR-3. AFL4 is an antagonist mAb.

References:
Kubo, H., T. Fujiwara, et al. (2000). "Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis." Blood 96(2): 546-53.
Saaristo, A., T. A. Partanen, et al. (2000). "Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors." Am J Pathol 157(1): 7-14.
Paavonen, K., P. Puolakkainen, et al. (2000). "Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing." Am J Pathol 156(5): 1499-504.
Larrivee, B. and A. Karsan (2000). "Signaling pathways induced by vascular endothelial growth factor (review)." Int J Mol Med 5(5): 447-56.