Anti-Mouse V beta 6 TCR APC

Description: This RR4-7 monoclonal antibody reacts with mouse V beta 6 TCR. Composed of an a and b chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement. The RR4-7 antibody recognizes the V beta 6 chain on T cells from mouse strains with the a (e.g., C57BR and SJL) and b haplotypes (e.g., BALB/c, C3H, and DBA/1). Reports indicate that strains expressing the Mls-1a antigen, particularly in the presence of MHC Class II I-E, possess fewer V beta 6 TCR+ T cells.

The RR4-7 antibody has been reported to have functional activity in vitro and in vivo.

References: Tang X, Maricic I, Kumar V. Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+ TCR alpha beta+ regulatory T cells and prevents experimental autoimmune encephalomyelitis. J Immunol. 2007 May 15;178(10):6043-50. (RR4-7, FC, FA)

Waldner H, Whitters MJ, Sobel RA, Collins M, Kuchroo VK. Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3412-7. (RR4-7, IHC-fr)

Anderson GD, Banerjee S, David CS. MHC class II A alpha and E alpha molecules determine the clonal deletion of V beta 6+ T cells. Studies with recombinant and transgenic mice. J Immunol. 1989 Dec 1;143(11):3757-61.

Kanagawa O, Palmer E, Bill J. The T cell receptor V beta 6 domain imparts reactivity to the Mls-1a antigen. Cell Immunol. 1989 Apr 1;119(2):412-26. (RR4-7)

MacDonald HR, Pedrazzini T, Schneider R, Louis JA, Zinkernagel RM, Hengartner H. Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens. J Exp Med. 1988 Jun 1;167(6):2005-10.