Anti-Mouse V beta 2 TCR FITC

Description: The B20.6 monoclonal antibody reacts with the mouse T-cell receptor (TCR) V beta 2 chain. Neonatal T cells which express V beta 2, and are exposed to the Balb/cV virus are eliminated during negative selection, while adult T cells expressing V beta 2 and exposed to the Balb/cV virus are clonally expanded.

References: Pircher H, Rebaï N, Groettrup M, Grégoire C, Speiser DE, Happ MP, Palmer E, Zinkernagel RM, Hengartner H, Malissen B. Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody. Eur J Immunol. 1992 Feb;22(2):399-404.

Necker A, Rebaï N, Matthes M, Jouvin-Marche E, Cazenave PA, Swarnworawong P, Palmer E, MacDonald HR, Malissen B. Monoclonal antibodies raised against engineered soluble mouse T cell receptors and specific for V alpha 8-, V beta 2- or V beta 10-bearing T cells. Eur J Immunol. 1991 Dec;21(12):3035-40.