Anti-Mouse TIM4 PE

Also known as: TIMD4, SMUCKLER

Clone: 54 (RMT4-54)

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 12-5866

Cat. No. Size
12-5866-80 25 ug
12-5866-82 100 ug
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Data for Anti-Mouse TIM4 PE.

Staining of Fc-blocked mouse resident peritoneal exudate cells with Anti-Mouse F4/80 Antigen...View More

  • Data for Anti-Mouse TIM4 PE.
Description

Description: The monoclonal antibody 54 recognizes mouse Tim-4 (T cell, Ig, mucin). Unlike other Tim family members, Tim-4 is not expressed on T lymphocytes but rather found on antigen presenting cells such as lymphoid and myeloid DC’s and macrophages. Tim-4 has been shown to interact with Tim-1 thereby suggesting a role of Tim-4 in the balance of Th1/Th2 regulation. Additionally Tim-4 has been shown to be a receptor for phosphatidylserine and may play a role in engulfment of apoptotic cells. Expression is found on a subset of CD11c+ splenic cells.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate PE
Laser Blue Laser, Green Laser, Yellow-Green Laser
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
46-5866 Anti-Mouse TIM-4 PerCP-eFluor® 710 488 nm 710 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
12-4321 Rat IgG2a K Isotype Control PE 488 - 561 nm FC RUO
14-0161 Anti-Mouse CD16/CD32 Purified FC, FA RUO
50-4801 Anti-Mouse F4/80 Antigen eFluor® 660 (Alexa Fluor® 647 Replacement) 633 - 647 nm 668 nm FC RUO
References

References: Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H. Bimodal regulation of T cell-mediated immune responses by TIM-4. Int Immunol. 2008 May;20(5):695-708.

Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1;180(7):4706-13.

Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 2007 Dec;27(6):927-40.