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Anti-Mouse TIGIT FITC

Also known as: VSTM3, WUCAM

Clone: GIGD7

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 11-9501

Cat. No. Size
11-9501-82 100 ug
11-9501-80 25 ug
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Data for Anti-Mouse TIGIT FITC.

Staining of BALB/c splenocytes with Anti-Mouse CD4 PE-eFluor® 610 (cat. 61-0042) and 1.0 ug of Rat...View More

  • Data for Anti-Mouse TIGIT FITC.
Description

Description: The GIGD7 monoclonal antibody reacts with mouse T cell immunoreceptor with Ig and ITIM domains (TIGIT, VSTM3, WUCAM), a 26 kDa protein that is a member of the poliovirus receptor (PVR) family. In mice, the expression of TIGIT has been reported in follicular T helper cells, while in humans, the expression of TIGIT has been reported on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells. TIGIT is not expressed on B cells or naïve CD4+ T cells. TIGIT is upregulated on CD4+ T cells following activation. TIGIT can interact with certain members of the PVR and PVR-like families, including CD155, and also mediates the interaction of NK cells and T cells with antigen presenting cells, fibroblasts and endothelial cells that express PVR and PVR-like proteins.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate FITC
Laser Blue Laser
Emit 520 nm
Excite 488 nm
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
46-9501 Anti-Mouse TIGIT PerCP-eFluor® 710 488 nm 710 nm FC RUO
12-9501 Anti-Mouse TIGIT PE 488 - 561 nm 578 nm FC RUO
16-9501 Anti-Mouse TIGIT Functional Grade Purified FC RUO
25-9501 Anti-Mouse TIGIT PE-Cyanine7 488 - 561 nm 775 nm FC RUO
50-9501 Anti-Mouse TIGIT eFluor® 660 633 - 647 nm 668 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
11-4321 Rat IgG2a K Isotype Control FITC 488 nm 520 nm FC, ICC, IHC RUO
61-0042 Anti-Mouse CD4 PE-eFluor® 610 488 - 561 nm 607 nm FC RUO
00-5523 Foxp3 / Transcription Factor Staining Buffer Set FC GPR
48-5773 Anti-Mouse/Rat Foxp3 eFluor® 450 405 nm 445 nm FC RUO
References

References: Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, Tomic A, Kvestak D, Babic M, Tsukerman P, Colonna M, Koszinowski U, Messerle M, Mandelboim O, Krmpotic A, Jonjic S. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. J Exp Med. 2016 Aug 22;213(9):1835-50. (GIGD7, FC, PubMed)

Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015 Nov 2;125(11):4053-62. (GIGD7, FC, PubMed)

Villegas-Mendez A, Shaw TN, Inkson CA, Strangward P, de Souza JB, Couper KN. Parasite-Specific CD4+ IFN-gamma+ IL-10+ T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection. Infect Immun. 2015 Oct 12;84(1):34-46. (GIGD7, FC, PubMed)

Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Leveque L, Chan CJ, Robb RJ, Markey KA, Alexander KA, Varelias A, Clouston AD, Smyth MJ, Macdonald KP, Hill GR. Promoting regulation via the inhibition of DNAM-1 after transplantation. Blood. 2013 Feb 21. PMID: 23430112 (GIGD7, FC, PubMed)

Seth S, Ravens I, Kremmer E, Maier MK, Hadis U, Hardtke S, Förster R, Bernhardt G. Abundance of follicular helper T cells in Peyer's patches is modulated by CD155. Eur J Immunol. 2009 Nov;39(11):3160-70.

Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63.

Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur J Immunol. 2009 Mar;39(3):695-703.

Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. 2009 Jan;10(1):48-57.


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