Mouse Th1/Th2 10plex Ready-to-Use FlowCytomix Multiplex

Description: The term TH1 cytokines (referred to also as Type-1 cytokines) and TH2 cytokines (referred to also as Type-2 cytokines) refers to the patterns of cytokines secreted by two different subpopulations of murine CD4 (+) T-cells that determine the outcome of an antigenic response toward humoral or cell-mediated immunity.

Numerous cells other than T-cells expressing CD4 have been shown to be capable of producing TH1 cytokines and TH2 cytokines. These cells include CD8 (+) T-cells, monocytes, natural killer cells, B-cells, eosinophils, mast cells, basophils, and other cells.

Type-1 cytokines include IL-2, IFN-gamma, IL-12 and TNF-beta, while Type-2 cytokines include IL-4, IL-5, IL-6, IL-10 and IL-13.

Type-1 helper cells (TH1), but not type-2 helper cells (TH2), secrete IL-2, IFN-gamma and TNF-beta, whereas TH2 cells, but not TH1 cells, express IL-4, IL-5, IL-6 and IL-10.

The molecular mechanisms underlying the evolution of these two different cell types from common precursors are still not completely known. Studies with transgenic mice carrying null mutations of the IL-4 gene have shown that IL-4 plays an important role in the establishment of a functional TH2 immune response.

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