Mouse Th1/Th2 10plex FlowCytomix Multiplex

Description: This Th1/Th2 10plex is a bead based Analyte Detection System for quantitative detection of mouse GM-CSF, IFN-gamma, IL-1alpha, IL-2, IL-4, IL-5, IL-6, IL-10, IL-17 and TNF-alpha by Flow Cytometry. BMS820FF is for research use only. Not for use in diagnostic or therapeutic procedures.

The term TH1 cytokines and TH2 cytokines refers to the patterns of cytokines secreted by two different subpopulations of murine CD4 + T cells that determine the outcome of an antigenic response toward humoral or cell-mediated immunity. Numerous cells other than T-cells expressing CD4 have been shown to be capable of producing TH1 cytokines and TH2 cytokines. These cells include CD8+ T-cells, monocytes, natural killer cells, B-cells, eosinophils, mast cells, basophils, and other cells. Type-1 cytokines include IL-2, IFN-gamma, IL-12 and TNF-beta, while
Type-2 cytokines include IL-4, IL-5, IL-6, IL-10 and IL-13.
Both types of TH cells influence each other by the Cytokines they secrete; IFN-gamma, for example, can down regulate TH2 clones while TH2 cytokines, such as IL-10 can suppress TH1 functions. IFN-gamma has been shown also to inhibit the proliferation of murine TH2 cells but not that of TH1 helper Tlymphocyte clones. It thus appears that these functional subsets are mutually antagonistic such that the decision of which subset predominates within an infection may determine also its outcome.

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