Mouse sCD40L Platinum ELISA

Description: The mouse sCD40L ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse sCD40L. The mouse sCD40L ELISA is for research use only. Not for diagnostic or therapeutic procedures.

The murine cell surface antigen is known also as Ly62. CD40 belongs to the TNF receptor superfamily and is a biochemical marker for the identification of activated platelets of patients with cardiovascular diseases (angina pectoris, infarction, stroke etc.)

A key role of CD40/CD40ligand interactions in immune activation, particularly in T-cell dependent B cell responses is anticipated. CD40 Ligand is expressed on the surface of activated CD4+ T cells, basophils, and mast cells. Binding of CD40L to its receptor, CD40, on the surface of B cells stimulates B-cell proliferation, adhesion and differentiation. A soluble isoform of CD40L has been shown to exist in the circulation.

Citations: Komura,K.; Fujimoto,M.; Yanaba,K.; Matsushita,T.; Matsushita,Y.; Horikawa,M.; Ogawa,F.; Shimizu,K.; Hasegawa,M.; Takehara,K.; Sato,S.. Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse. Annals of the Rheumatic Diseases 2008;67:867-872. (Link)

Welch,Carrie L.; Sun,Yu; Arey,Brian J.; Lemaitre,Vincent; Sharma,Naresh; Ishibashi,Minako; Sayers,Scott; Li,Rong; Gorelik,Anna; Pleskac,Nick; Collins-Fletcher,Kadesha; Yasuda,Yoshiyuki; Bromme,Dieter; D'Armiento,Jeanine M.; Ogletree,Martin L.; Tall,Alan R.. Spontaneous Atherothrombosis and Medial Degradation in Apoe-/-, Npc1-/- Mice. Circulation 2007;116:2444-2452. (Link)

References: Rathmell,J.C.; Townsend,S.E.; Xu,J.C.; Flavell,R.A.; Goodnow,C.C.. Expansion or elimination of B cells in vivo: dual roles for. Cell 1996;87:319-329. (Link)

Tsubata,T.; Murakami,M.; Nisitani,S.; Honjo,T.. Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice. Philos.Trans R Soc.Lond B Biol.Sci. 1994;345:297-301. (Link)

Holder,M.J.; Wang,H.; Milner,A.E.; Casamayor,M.; Armitage,R.; Spriggs,M.K.; Fanslow,W.C.; MacLennan,I.C.; Gregory,C.D.; Gordon,J.; .. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bc1-2 induction. Eur.J.Immunol. 1993;23:2368-2371. (Link)

Cosman,D.. A family of ligands for the TNF receptor superfamily. Stem Cells 1994;12:440-455. (Link)

Lane,P.; Brocker,T.; Hubele,S.; Padovan,E.; Lanzavecchia,A.; McConnell,F.. Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation. J.Exp.Med. 1993;177:1209-1213. (Link)

Brugnoni,D.; Rossi,G.; Tucci,A.; Cattaneo,R.; Airo,P.. Study of CD40 ligand expression in B-cell chronic lymphocytic leukemia. Haematologica 1995;80:440-442. (Link)