Anti-Mouse/Rat MHC Class II (I-Ek) Purified

Description: The 14-4-4S monoclonal antibody reacts with the mouse and rat major histocompatibility complex class II, I-E subregion-encoded glycoprotein in mice strains of H-2^k, H-2^d, H-2^p and H-2^r. H-2^b, H-2^f and H-2^s haplotypes do not express the I-E antigen. MHC class II is present on B cells, monocytes, macrophages, and dendritic cells. The 14-4-4S mAb has been reported to block antigen presentation in in vitro assays. This antibody cross-reacts with rat.

References:
Farr A, DeRoos PC, Eastman S, Rudensky AY. Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells. Eur J Immunol. 1996 Dec;26(12):3185-93.
Spencer JS, Freed JH, Kubo RT. Expression and function of mixed isotype MHC class II molecules in normal mice. J Immunol. 1993 Dec 15;151(12):6822-32.
Pruitt SK, Baldwin WM 3rd, Barth RN, Sanfilippo F. The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts. Transplantation. 1993 Dec;56(6):1318-24.
Liu H, Steiner BM, Alder JD, Baertschy DK, Schell RF. Immune T cells sorted by flow cytometry confer protection against infection with Treponema pallidum subsp. pertenue in hamsters. Infect Immun. 1990 Jun;58(6):1685-90.
Maloy WL, Ozato K, Sachs DH, Coligan JE. Evidence for the association of I-A and I-E molecules in d-haplotype mice. Mol Immunol. 1986 Mar;23(3):263-9.