Anti-Mouse/Rat CXCL12 beta (SDF-1 beta) Purified

Description: The polyclonal antibody reacts with both mouse and rat CXCL12 β (SDF-1β) and was generated using E. coli-expressed mouse CXCL12 β as an immunogen. CXCL12 β, also known as pre-B-cell growth-stimulating factor (PBSF) and stromal cell-derived factor-beta (SDF-1β), is a 74-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of CXCL12 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice. CXCL12 has been shown to be chemotactic for lymphocytes. In addition, CXCL12 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells. CXCL12 binding to CXCR4 inhibits HIV-1 entry.

References:
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Nagasawa, T et al. 1994. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl. Acad. Sci. USA 91:2305-2309.
Nagasawa, T. et al. 1996. Defeats of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 328:635-638.
Bleul. C.C. et al. 1996. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. EXP. Med. 184:1101-1109.
Bleul. C.C. et al. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
Oberlin E. et al. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by C-cell-line-adapted HIV-1. Nature 382:833-835.