Anti-Mouse/Rat CXCL12 alpha (SDF-1 alpha) Purified

Description: The polyclonal antibody reacts with both mouse and rat SDF-1α and was generated using E. coli-expressed mouse SDF-1α as an immunogen. SDF-1α (stromal cell-derived factor-1 alpha), also known as pre-B-cell growth-stimulating factor (PBSF), is a 70-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of the SDF-1 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis. SDF-1 has been shown to be chemotactic for lymphocytes. In addition, SDF-1 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV-1 entry.

References:
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