Anti-Mouse/Rat CD61 (Integrin beta 3) Functional Grade Purified

Description: The 2C9.G3 (HMb3-1) monoclonal antibody reacts with mouse and rat CD61, also known as the integrin β₃. CD61 is expressed by activated T cells, granulocytes, and platelet. CD61 associates non-covalently with two integrin α subunits; α_V (CD51) to form Vitronectin Receptor and α_Iib (CD41) to form gpIIb/IIIa. These heterodimeric complexes are responsible for adhesion to extracellular matrix components including fibrinogen, fibronectin, fibronectin, vitronectin, thrombospondin and von Willebrand factor.

References:
Yasuda M, Hasunuma Y, Adachi H, Sekine C, Sakanishi T, Hashimoto H, Ra C, Yagita H, Okumura K. 1995. Expression and function of fibronectin binding integrins on rat mast cells. Int Immunol. 7:251-8.

Nohara K, Pan X, et al. 2005. Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. J Immunol. 174(5):2770-7. (FC, PubMed)