Anti-Mouse/Rat CD29 PerCP-eFluor® 710

Description: The eBioHMb1-1 monoclonal antibody reacts with mouse and rat CD29 (integrin β₁), a 110-120 kDa member of the β integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the α integrins CD49a-f to form the VLA-1 through VLA-6 complexes, as well as with CD51. These αβ integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins can also interact with cellular receptors such as VCAM-1 and MadCAM-1.

References: Ridger VC, Wagner BE, Wallace WA, Hellewell PG. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. J Immunol. 2001 Mar 1;166(5):3484-90. (HMbeta1-1, FA, PubMed)

Noto K, Kato K, Okumura K, Yagita H. Identification and functional characterization of mouse CD29 with a mAb. Int Immunol. 1995 May;7(5):835-42. (HMbeta1-1, mAb development, IP, FA, PubMed)