Anti-Mouse/Rat CD29 APC

Description: The eBioHMb1-1 monoclonal antibody reacts with mouse and rat CD29 (integrin β₁), a 110-120 kDa member of the β integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the α integrins CD49a-f to form the VLA-1 through VLA-6 complexes, as well as with CD51. These αβ integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins can also interact with cellular receptors such as VCAM-1 and MadCAM-1.

References: Noto K, Kato K, Okumura K, Yagita H. Identification and functional characterization of mouse CD29 with a mAb.Int Immunol. 1995 May;7(5):835-42. (HMbeta1-1, mAb development, IP, FA, PubMed)

Ridger VC, Wagner BE, Wallace WA, Hellewell PG. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.J Immunol. 2001 Mar 1;166(5):3484-90. (HMbeta1-1, FA, PubMed)