Anti-Mouse/Rat CD278 (ICOS) FITC

Also known as: Inducible T-cell COStimulator

Clone: C398.4A

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 11-9949

Cat. No. Size
11-9949-80 25 ug
11-9949-82 100 ug

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Data for Anti-Mouse/Rat CD278 (ICOS) FITC.

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  • Data for Anti-Mouse/Rat CD278 (ICOS) FITC.
  • Data for Anti-Mouse/Rat CD278 (ICOS) FITC.
Description

Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).

Details
Host Armenian Hamster
Isotype IgG
Reactivity Mouse, Rat
Conjugate FITC
Laser Blue Laser
Emit 518 nm
Excite 488 nm
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

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Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-9949 Anti-Mouse/Rat CD278 (ICOS) PE 488 nm 575 nm FC RUO
15-9949 Anti-Mouse/Rat CD278 (ICOS) PE-Cy5 488 nm 670 nm FC RUO
14-9949 Anti-Mouse/Rat CD278 (ICOS) Purified FC, IHC, FA, IP RUO
16-9949 Anti-Mouse/Rat CD278 (ICOS) Functional Grade Purified FC, FA RUO
13-9949 Anti-Mouse/Rat CD278 (ICOS) Biotin FC RUO
References

References: Arimura Y, Shiroki F, Kuwahara S, Kato H, Dianzani U, Uchiyama T, Yagi J. Akt is a neutral amplifier for Th cell differentiation. J Biol Chem. 2004 Mar 19;279(12):11408-16. [activating]

Lucia, M. B., D. Buonfiglio, et al. 2000. Expression of the novel T cell activation molecule hpH4 in HIV-infected patients: correlation with disease status. AIDS Res Hum Retroviruses 16(6): 549-57.

Buonfiglio, D., M. Bragardo, et al. 1999. Characterization of a novel human surface molecule selectively expressed by mature thymocytes, activated T cells and subsets of T cell lymphomas. Eur J Immunol 29(9): 2863-74.

Redoglia, V., U. Dianzani, et al. 1996. Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor. Eur J Immunol 26(11): 2781-9.


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