Anti-Mouse/Rat CD178 (Fas Ligand) Purified

Description: The MFL4 monoclonal antibody reacts with mouse and rat Fas Ligand (CD178), a 40 kDa type II transmembrane glycoprotein. FasL is a member of the TNF family and is expressed by activated T cells. The interaction of FasL with its receptor CD95 induces Fas-mediated killing. It has been reported that the human FasL antigen is cleaved from the surface by matrix metalloproteinases (MMPs), resulting in a 26 kDa soluble form. The degree of sensitivity for the mouse and rat antigens to MMPs has not been reported. MFL4 has been reported in the literature to cross-react with the rat FasL antigen.

References: Kayagaki, N., N. Yamaguchi, et al. 1997. Polymorphism of murine Fas ligand that affects the biological activity. Proc Natl Acad Sci U S A 94(8): 3914-9.
Nakajima, A., H. Hirai, et al. 2000. Treatment of lupus in NZB/W F1 mice with monoclonal antibody against fas ligand. J Autoimmun 14(2): 151-7.
Kayagaki, N., A. Kawasaki, et al. 1995. Metalloproteinase-mediated release of human Fas ligand. J Exp Med 182(6): 1777-83.
Trinite, B., C. Voisine, et al. 2000. A subset of cytolytic dendritic cells in rat. J. Immunol. 165(8): 4202-8