Anti-Mouse/Rat CCL3 (MIP-1 alpha) Purified

Description: The CCL3 polyclonal antibody reacts with both mouse and rat CCL3, also known as MIP-1α (macrophage inflammatory protein-1 alpha). The antibody was generated using E. coli-expressed amino acids 1-69 of mature rat CCL3 as an immunogen. CCL3 is a 69-amino acid CC chemokine with a molecular weight of 7.9 kDa. CCL3 induces migration of monocytes/macropages, B lymphocytes, activated CD8⁺ T cells, natural killer (NK) cells, and eosinophils. CCL3 also stimulates basophils to release histamine, induces ICAM-1 expression, mast cell degranulation, and production of TNF-α, IL-1 and IL-6. In addition to its proinflammatory activities, CCL3 inhibits the proliferation of hematopoietic stem cells in vitro and in vivo. Cross-reactivity to CCL3 of other species has not been determined.

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