Anti-Mouse/Rat CCL5 (RANTES) Purified (To be Discontinued; refer to monoclonal Cat. No. 14-7085)

Description: The polyclonal antibody reacts with both mouse and rat RANTES and was generated using E. coli-expressed amino acid 1-70 of mature rat RANTES as an immunogen. RANTES (regulated upon activation, normal T-cell expressed and secreted) is a 70-amino acid CC chemokine originally cloned from T cell-specific sequence-enriched cDNA libraries. Both human and murine RANTES are chemotactic for monocytes. Human RANTES is also a chemoattractant for T cells and eosinophils, as well as an activator of basophils for histamine release. In contrast to other CC chemokines, RANTES is only slowly expressed after activation of leukocytes. It is involved in a number of pathological conditions like chronic inflammation and autoimmune diseases.

References:
Schall, T.J. 1988. A human T cell-specific molecule is a member of a new gene family. J Immunol. 141:1018-1025
Schall, T. et al. 1992. Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man. Eur J Immunol 22:1477
Neilson,E.G., et al. 1992. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes: A small intercrine from the Scy superfamily. Kidney Int. 41:220-225
Haelens, A. et al., 1996. Leukocyte migration and activation by murine chemokines. Immunobiol. 195:499-521