Anti-Mouse/Rat CCL5 (RANTES) Purified (To be Discontinued; refer to monoclonal Cat. No. 14-7085)

Also known as: CCL-5

Clone: Polyclonal

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Alternative monoclonal available. Refer to Cat. No. 14-7085.

SKU# 14-7993

Cat. No. Size
14-7993-85 500 ug
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Data for Anti-Mouse/Rat CCL5 (RANTES) Purified.

Description

Description: The polyclonal antibody reacts with both mouse and rat RANTES and was generated using E. coli-expressed amino acid 1-70 of mature rat RANTES as an immunogen. RANTES (regulated upon activation, normal T-cell expressed and secreted) is a 70-amino acid CC chemokine originally cloned from T cell-specific sequence-enriched cDNA libraries. Both human and murine RANTES are chemotactic for monocytes. Human RANTES is also a chemoattractant for T cells and eosinophils, as well as an activator of basophils for histamine release. In contrast to other CC chemokines, RANTES is only slowly expressed after activation of leukocytes. It is involved in a number of pathological conditions like chronic inflammation and autoimmune diseases.

Details
Host Rabbit
Isotype IgG
Reactivity Mouse, Rat
Conjugate Purified
Reported Applications Western Blotting
Documentation
TDS Link Download TDS
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References

References:
Schall, T.J. 1988. A human T cell-specific molecule is a member of a new gene family. J Immunol. 141:1018-1025
Schall, T. et al. 1992. Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man. Eur J Immunol 22:1477
Neilson,E.G., et al. 1992. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes: A small intercrine from the Scy superfamily. Kidney Int. 41:220-225
Haelens, A. et al., 1996. Leukocyte migration and activation by murine chemokines. Immunobiol. 195:499-521


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