Anti-Mouse RAE1 delta PE

Description: The RD-41 monoclonal antibody reacts with the murine Rae1δ. Rae-1δ is one of several known murine NKG2D ligands that include RAE-1 molecules (α, β, ε, γ and δ), H60 and MULT-1. Expression of NKG2D ligands is low or absent on normal adult tissues. However, stressed or transformed cells express NKG2D ligands which in turn activates NK cells tumoricidal activity through NKG2D. Until now, the expression of NKG2D ligands has been mainly studied with NKG2D tetramers which recognizes all NKG2D ligands. The RD-41 antibody has been reported to block tetramer staining.

References: Diefenbach A, Jamieson AM, Liu SD, Shastri N, Raulet DH.Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.Nat Immunol. 2000 Aug;1(2):119-26.

Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH, Lanier LL.Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.Immunity. 2000 Jun;12(6):721-7.

O'Callaghan CA, Cerwenka A, Willcox BE, Lanier LL, Bjorkman PJ.Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.Immunity. 2001 Aug;15(2):201-11.

Diefenbach A, Jensen ER, Jamieson AM, Raulet DH.Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity.Nature. 2001 Sep 13;413(6852):165-71.

Carayannopoulos LN, Naidenko OV, Kinder J, Ho EL, Fremont DH, Yokoyama WM.Ligands for murine NKG2D display heterogeneous binding behavior.Eur J Immunol. 2002 Mar;32(3):597-605.