Anti-Mouse Nur77 PE

Description: This 12.14 monoclonal antibody reacts with mouse Nur77 (also known as NR4A1, TR3, NGFI-B, or NAK1), an inducible orphan nuclear receptor. Expressed in thymocytes and T cell lines, Nur77 promotes apoptosis and plays a role in thymocyte negative selection. Additionally, Nur77 has been shown to be critical for steroid biosynthesis in Leydig cells as well as for the effects of dopamine. In addition, Nur77 has been shown to interact with FoxP3 in regulatory T cells. However, our results with this antibody do not correlate with this observation.

References: Martin LJ, Boucher N, Brousseau C, Tremblay JJ.The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I. Mol Endocrinol. 2008 Sep;22(9):2021-37.

Bourhis E, Maheux J, Rouillard C, Lévesque D.Extracellular signal-regulated kinases (ERK) and protein kinase C (PKC) activities are involved in the modulation of Nur77 and Nor-1 expression by dopaminergic drugs. J Neurochem. 2008 Jul;106(2):875-88.

Tao R, Hancock W. Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival. PLoS ONE. 2008 May 28;3(5):e2321.

Cunningham NR, Artim SC, Fornadel CM, Sellars MC, Edmonson SG, Scott G, Albino F, Mathur A, Punt JA.Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation. J Immunol. 2006 Nov 15;177(10):6660-6.