Mouse NGF beta Recombinant Protein

Description: Nerve Growth Factor-beta (NGF-b) is a neurotrophic factor that plays a crucial role in the regulation of growth and differentiation of sympathetic and sensory neurons. NGF is a 7S complex comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for the NGF growth stimulating activity. It has been reported that NGF-b promotes B cells differentiation and survival. Mouse NGF-b produced in E. coli is a non-glycosylated homodimer, with each monomer containing 120 amino acids of 13.5 kDa.

References: Abram M, Wegmann M, Fokuhl V, Sonar S, Luger EO, Kerzel S, Radbruch A, Renz H, Zemlin M. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol. 2009 Apr 15;182(8):4705-12.

Kronfeld I, Kazimirsky G, Gelfand EW, Brodie C. NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta. Eur J Immunol. 2002 Jan;32(1):136-43.

Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Dello Sbarba P, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F. Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem. 2001 Oct 19;276(42):39027-36.

Ramer, M. S. Priestley, J. V. McMahon, S. B. Functional regeneration of sensory axons into the adult spinal cord. Nature 2000;403: 312-316.

Sanico, A. M. Stanisz, A. M. Gleeson, T. D. Bora, S. Proud, D. Bienenstock, J. Koliatsos, V. E. Togias, A. Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am. J. Resp. Crit. Care Med. 2000;161: 1631-1635.

Ullrich, A. Gray, A. Berman, C. Dull, T. J. Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature 1983;303: 821-825.