Mouse MIP-1 beta FlowCytomix Simplex

Description: This FlowCytomix Simplex Kit is designed for the measurement of Mouse MIP-1beta in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Mouse Basic Kit (cat. BMS8440FF), this kit can be used to detect MIP-1beta alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.

This kit contains bead population B2.

MIP-1alpha and MIP-1beta belong to the family of cysteine-cysteine (cc) chemokines, RANTES being another prominent member thereof.

Both MIP-1alpha and MIP-1beta are not only chemoattractants but also coactivators of macrophages acting in concert with IFN-gamma as type 1 cytokines.
MIP-1alpha and MIP-1beta are distinct but highly homologous chemokines produced by a variety of host cells in response to various external stimuli and share affinity for their receptor CCR5. The roles of MIP-1alpha and MIP-1beta have been elucidated in response to their affects on cellular and humoral immune response. MIP-1alpha was shown to stimulate strong antigen specific responses, while MIP-1beta promotes antibody responses. Both macrophage inflammatory proteins are however strictly associated with type 1 immune response.

Determination of the expression levels of the MIP-1s turned out to provide important information regarding numerous diseases such as multiple myeloma, allergic asthmatic disorders, acute experimental autoimmune encephalomyelitis, HIV infection, sarcoidosis and sepsis.

Citations: Binder,Nikolaus; Niederreiter,Birgit; Hoffmann,Oskar; Stange,Richard; Pap,Thomas; Stulnig,Thomas; Mack,Matthias; Erben,Reinhold; Smolen,Josef; Redlich,Kurt. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med 2009;15:417-424. (Link)