Anti-Mouse MHC Class II (I-Ak alpha) PerCP-eFluor® 710

Description: This 11-5.2 monoclonal antibody reacts with the alpha chain of the mouse MHC Class II I-Ak alloantigen. This antibody also recognizes mouse strains with the H-2f haplotype. Reactivity to other haplotypes (e.g., b, d, f, p, q, and s) has not been observed.

References: Blander JM, Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature. 2006 Apr 6;440(7085):808-12. (11-5.2, ICC)

Li YS, Kanamoto N, Hataya Y, Moriyama K, Hiratani H, Nakao K, Akamizu T. Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent autoimmune thyroid diseases. Endocrinology. 2004 May;145(5):2524-30. (11-5.2, FC)

Sprent J, Lerner EA, Bruce J, Symington FW. Inhibition of T cell activation in vivo with mixtures of monoclonal antibodies specific for I-A and I-A/E molecules. J Exp Med. 1981 Jul 1;154(1):188-92. (11-5.2, FA)