Anti-Mouse MHC Class II I-Ad APC

Description: This AMS-32.1 monoclonal antibody reacts with the mouse MHC Class II I-Ad alloantigen, which is present on mouse strains such as Balb/c and DBA/2. This antibody also recognizes the H-2f, H-2g7, H-2i, and H-2v haplotypes. However, reactivity to other haplotypes (e.g., b, k, p, q, r, s, and u) has not been observed.

References: Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest. 2010 Apr 1;120(4):1324-36. (AMS-32.1, FC)

Martinic MM, Rülicke T, Althage A, Odermatt B, Höchli M, Lamarre A, Dumrese T, Speiser DE, Kyburz D, Hengartner H, Zinkernagel RM. Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1861-6. (AMS-32.1, IHC-frozen)

Lorber MI, Loken MR, Stall AM, Fitch FW. I-A antigens on cloned alloreactive murine T lymphocytes are acquired passively. J Immunol. 1982 Jun;128(6):2798-803. (AMS-32.1, FC)