Anti-Mouse MHC Class I (H-2Kd) Functional Grade Purified

Description: This SF1-1.1.1 monoclonal antibody reacts with the H-2Kd MHC class I alloantigen. H-2Kd is involved in antigen presentation to T cells expressing CD3/TCR and CD8. Reactivity to other haplotypes (e.g. b, j, k, p, q, s, and v) has not been observed.

This monoclonal antibody has been reported to block CD8 involvement in TCR-ligand binding.

References: Noun G, Reboul M, Abastado JP, Jaulin C, Kourilsky P, Pla M. Alloreactive monoclonal antibodies select Kd molecules with different peptide profiles. J Immunol. 1996 Sep 15;157(6):2455-61. (SF1-1.1.1, FC and ELISA, Pubmed)

Renard V, Romero P, Vivier E, Malissen B, Luescher IF. CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding. J Exp Med. 1996 Dec 1;184(6):2439-44. (SF1-1.1.1, FA, Pubmed)

Luescher IF, Vivier E, Layer A, Mahiou J, Godeau F, Malissen B, Romero P. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature. 1995 Jan 26;373(6512):353-6. (SF1-1.1.1, FA, Pubmed)