Anti-Mouse MHC Class I H-2Dk APC

Description: This 15-5-5 monoclonal antibody reacts with mouse MHC Class I H-2Dk alloantigen. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4.

The 15-5-5 antibody crossreacts with the H-2Kd and H-2f haplotypes. However, reactivity to other haplotypes (i.e., a, b, p, q, r, and s) has not been observed. Moreover, this antibody has been reported to be cytotoxic to H-2Dk cells.

References: Tsuji H, Kawaguchi S, Wada T, Nagoya S, Inobe M, Yagita H, Okumura K, Yamashita T, Uede T. Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer. Cancer Gene Ther. 2003 Sep;10(9):717-25. (15-5-5, FC)

Ward PL, Koeppen HK, Hurteau T, Rowley DA, Schreiber H. Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance. Cancer Res. 1990 Jul 1;50(13):3851-8. (15-5-5, FC)

Ozato K, Mayer N, Sachs DH. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol. 1980 Feb;124(2):533-40. (15-5-5, FA)