Anti-Mouse MAdCAM-1 Functional Grade Purified

Also known as: mucosal vascular addressin cell adhesion molecule , MAdCAM1

Clone: MECA-367

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 16-5997

Cat. No. Size
16-5997-85 500 ug
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Data for Anti-Mouse MAdCAM-1 Functional Grade Purified.

Surface staining of mouse TNF alpha stimulated bEnd.3 cell line with Anti-Mouse MAdCAM-1 FITC. ...View More

  • Data for Anti-Mouse MAdCAM-1 Functional Grade Purified.
Description

Description: The MECA-367 monoclonal antibody reacts with mouse mucosal vascular addressin-1 (MAdCAM-1), a 50-60 kDa member of the Ig superfamily. This antigen is expressed in mucosal lymphoid tissue and lamina propria and is a counter-receptor for CD62L and CD49d. MAdCAM-1 is involved in homing of subpopulation of memory T cells to the gut lamina propria, and recirculation of naïve lymphocytes in Peyer’s patches and mesenteric lymph nodes.

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Reported Applications Flow Cytometric Analysis, Functional Assays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-5997 Anti-Mouse MAdCAM-1 Purified FC RUO
13-5997 Anti-Mouse MAdCAM-1 Biotin FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
16-4321 Rat IgG2a K Isotype Control Functional Grade Purified FC RUO
References

References: Streeter, P. R., B. T. Rouse, et al. (1988). Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol 107(5): 1853-62.

Streeter, P. R., E. L. Berg, et al. (1988). A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature 331(6151): 41-6.

Glanville SH, Bekiaris V, Jenkinson EJ, Lane PJ, Anderson G, Withers DR. Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization. Eur J Immunol. 2009 Jan;39(1):280-9. (MECA-367, IF, PubMed)

Withers DR, Kim MY, Bekiaris V, Rossi SW, Jenkinson WE, Gaspal F, McConnell F, Caamano JH, Anderson G, Lane PJ The role of lymphoid tissue inducer cells in splenic white pulp development. Eur J Immunol. 2007 Nov;37(11):3240-5. (MECA-367, IF, PubMed)

Fernekorn U, Butcher EC, Behrends J, Hartz S, Kruse A. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol. 2004 Dec;34(12):3423-33. (MECA-367, blocking, PubMed)

Coisne C, Dehouck L, Faveeuw C, Delplace Y, Miller F, Landry C, Morissette C, Fenart L, Cecchelli R, Tremblay P, Dehouck B. Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab Invest. 2005 Jun;85(6):734-46. (MECA-367, IF, PubMed)

Leung E, Kanwar RK, Kanwar JR, Krissansen GW. Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells. Immunol Cell Biol. 2003 Aug;81(4):320-7. (MECA-367, IF, PubMed)