Anti-Mouse MAdCAM-1 Biotin

Description: The MECA-367 monoclonal antibody reacts with mouse mucosal vascular addressin-1 (MAdCAM-1), a 50-60 kDa member of the Ig superfamily. This antigen is expressed in mucosal lymphoid tissue and lamina propria and is a counter-receptor for CD62L and CD49d. MAdCAM-1 is involved in homing of subpopulation of memory T cells to the gut lamina propria, and recirculation of naïve lymphocytes in Peyer’s patches and mesenteric lymph nodes.

References: Streeter, P. R., B. T. Rouse, et al. (1988). Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes." J Cell Biol 107(5): 1853-62.

Streeter, P. R., E. L. Berg, et al. (1988). "A tissue-specific endothelial cell molecule involved in lymphocyte homing." Nature 331(6151): 41-6.

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.Glanville SH, Bekiaris V, Jenkinson EJ, Lane PJ, Anderson G, Withers DR.Eur J Immunol. 2009 Jan;39(1):280-9. (MECA-367, IF, PubMed)

The role of lymphoid tissue inducer cells in splenic white pulp development.Withers DR, Kim MY, Bekiaris V, Rossi SW, Jenkinson WE, Gaspal F, McConnell F, Caamano JH, Anderson G, Lane PJ.Eur J Immunol. 2007 Nov;37(11):3240-5. (MECA-367, IF, PubMed)

Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus.Fernekorn U, Butcher EC, Behrends J, Hartz S, Kruse A.Eur J Immunol. 2004 Dec;34(12):3423-33. (MECA-367, blocking, PubMed)

Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium.Coisne C, Dehouck L, Faveeuw C, Delplace Y, Miller F, Landry C, Morissette C, Fenart L, Cecchelli R, Tremblay P, Dehouck B.Lab Invest. 2005 Jun;85(6):734-46. (MECA-367, IF, PubMed)

Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells.Leung E, Kanwar RK, Kanwar JR, Krissansen GW.Immunol Cell Biol. 2003 Aug;81(4):320-7. (MECA-367, IF, PubMed)